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Planta Med 2003; 69(11): 973-983
DOI: 10.1055/s-2003-45141
Review
© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Compounds of Plant Origin. Part I. Action on Arachidonic Acid Pathway, Nitric Oxide and Nuclear Factor κ B (NF-κB)

João B. Calixto1 , Michel F. Otuki1 , Adair R.S. Santos2
  • 1Department of Pharmacology, CCB, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
  • 2Department of Physiological Sciences, CCB, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
Michel Otuki is a PhD student in Pharmacology and he thanks Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for fellowship support. The studies from our group were supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP) and by Programa de Apoio aos Grupos de Excelência (PRONEX), Brazil.
Further Information

Publication History

Received: March 21, 2003

Accepted: June 19, 2003

Publication Date:
09 January 2004 (online)

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Abstract

Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-κB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases.

Abbreviations

AP-1:activator protein-1

CAPE:caffeic acid phenethyl ester

COX:cyclooxygenase

ELAM-1:endothelial-leukocyte adhesion molecule-1

ICAM-1:intercellular adhesion molecule-1

IL:interleukin

iNOS:inducible nitric oxide synthase

LO:lipoxygenase

LPS:lipopolysaccharide

LT:leukotriene

MPO:myeloperoxidase

NF-κB:nuclear factor kappa B

NO:nitric oxide

PGE2:prostaglandin E2

TXA2:thromboxane A2

PLA2:phospholipase A2

PKC:protein kinase C

PMA/TPA:phorbol myristate acetate

TGF-β1:transforming growth factor-β1

TNF-α:tumour necrosis factor

CAM-1:vascular cell adhesion molecule-1

Key words

Medicinal plants - plant constituents - inflammation

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João B. Calixto

Department of Pharmacology

UFSC

Rua Ferreira Lima 82

88015-420, Florianópolis, SC

Brazil

Phone: +55-48-3319491

Fax: +55-48-2224164

Email: calixto@farmaco.ufsc.br or calixto3@terra.com.br

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