REGULAR ARTICLEActivity of various CART peptides in changing locomotor activity in the rat
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Cited by (39)
CART modulates the effects of levodopa in rat model of Parkinson's disease
2016, Behavioural Brain ResearchInvolvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats
2015, NeuroToxicologyCitation Excerpt :In addition, CART peptide is a modulator of dopamine and psychostimulants because CART tends to oppose large increases in dopamine signaling (Hubert et al., 2008) and prevent the oxidative stress in the brain (Balkan et al., 2012; Sha et al., 2014). There are two active CART peptide fragments, i.e. CART (55–102) and CART (62–102), that exhibit different relative activities in different testing paradigms (Kimmel et al., 2002). CART (55–102) is five-fold more potent than CART (62–102) in the inhibition of food intake (Rohner-Jeanrenaud et al., 2002; Vicentic et al., 2006).
Regulation of the mesolimbic dopamine circuit by feeding peptides
2015, NeuroscienceCitation Excerpt :However, a few studies have implicated CART action in the VTA for its anorexigenic effects. Intra-VTA injection of CART dose-dependently increases locomotor activity and induces a CPP (Kimmel et al., 2000, 2002). However, intra-VTA CART55–102 reduces locomotor activating effects of systemic cocaine (Jaworski et al., 2003, 2007).
Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control
2015, Hormones and BehaviorCitation Excerpt :Thus, it is possible that CART may participate in regulating NPY- and POMC-mediated appetite control in AMPH-treated rats. There are two active CART peptide fragments, CART (55–102) and CART (62–102), that exhibit different relative activities in different testing paradigms (Kimmel et al., 2002). CART (55–102) is five-fold more potent than CART (62–102) in the inhibition of food intake (Vicentic et al., 2006).
CART in the brain of vertebrates: Circuits, functions and evolution
2014, PeptidesCitation Excerpt :However, no such effect was observed by Couceyro et al. [71]. CART 55–102, as well as 62–102, stereotaxically injected in the ventral tegmental area (VTA) stimulated locomotor activity with immediate effect, while some other fragments were ineffective [169,170]. The intra-accumbal administration of shRNAs against CART peptides caused about 2.5-fold increase in cocaine-mediated locomotion [153].