Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid
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Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosis
2019, Journal of Cystic FibrosisAn important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)
2017, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :Similarly, in humans, the effects of BAs occur through FXR- and SHP-mediated repression of retinoic acid receptor/retinoid X receptor (RAR/RXR)-induced activation of the ASBT [20]. Different investigators have observed that the SLC10A2 gene is upregulated, downregulated, or neither by BAs [15–17,21–24]. The difference not only in the various investigated species, but in the lack of unification among experimental models that assess the effects of changes in the BA level on the expression and function of the ASBT might account for the discrepancies that have been observed [15,18,20,25,26].
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2012, GastroenterologyDefects in gallbladder emptying and bile acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficiencies
2012, GastroenterologyCitation Excerpt :Fgf15, Shp, Ibabp, and Ostα/β all are up-regulated by BAs. The regulation of Asbt gene expression remains controversial, but there is evidence to indicate that BAs increase ileal Asbt levels.25 We infer that lower levels of BA transporters, such as ASBT and OSTα/β, in enterocytes decreased the intestinal absorption of BAs.
Bile Formation and the Enterohepatic Circulation
2012, Physiology of the Gastrointestinal Tract, Two Volume SetBile Formation and the Enterohepatic Circulation
2012, Physiology of the Gastrointestinal Tract