Issue 1235, 1979
From the journal:

Analyst

Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide

Pamela Girgis-Takla  and  Loannis Chroneos  

Abstract

A sensitive method is described for the fluorimetric determination of acetohexamide in plasma or in tablets by means of its reaction with 1-methyl-nicotinamide, which is shown to be a useful reagent for the determination of ketonic compounds. The limit of detection is approximately 0.2 µg ml–1 and the relative standard deviation is 3.1% for 2 µg ml–1 in plasma. Acetoacetic acid usually does not interfere, but can be separated, if necessary, from acetohexamide by means of a washing technique. No interference is caused by the presence of insulin, other (non-ketonic) oral hypoglycaemic drugs, acetone or pyruvic or α-ketoglutaric acid.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/AN9790400117
Article type
Paper

Analyst, 1979,104, 117-123

Permissions

Request permissions

Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide

P. Girgis-Takla and L. Chroneos, Analyst, 1979, 104, 117 DOI: 10.1039/AN9790400117

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements