Issue 1, 2009
From the journal:

Organic & Biomolecular Chemistry

Switchable electrostatic interactions between gold nanoparticles and coiled coilpeptides direct colloid assembly†

Sara C. Wagner,a   Meike Roskamp,b   Helmut Cölfen,c   Christoph Böttcher,d   Sabine Schlecht*b  and  Beate Koksch*a  

* Corresponding authors

a Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, Germany
E-mail: koksch@chemie.fu-berlin.de
Fax: +49 30 838 55644
Tel: +49 30 838 55344

b Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstraße 34–36, Germany
E-mail: schlecht@chemie.fu-berlin.de
Fax: +49 30 838 53310
Tel: +49 30 838 52423

c Department of Colloid Chemistry, Max-Planck-Institute of Colloids and Interfaces, Germany

d Research Centre for Electron Microscopy, Freie Universität Berlin, Fabeckstraße 36a, Germany

Abstract

The nanoparticle–peptide interaction described here is based on electrostatic forces and the pH value can act as a trigger to direct the organization of functionalized nanoparticles in a reversible and repeatable manner. The ability of the peptide to interact with the charged gold nanoparticles is directly related to its helical structure and was not found for a random coil peptide with the same net charge. Interestingly, the interaction with nanoparticles seems to induce a fibrillation of the coiled coil peptide.

Graphical abstract: Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly

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Article information

DOI
https://doi.org/10.1039/B813429D
Article type
Paper
Submitted
04 Aug 2008
Accepted
01 Oct 2008
First published
17 Nov 2008

Org. Biomol. Chem., 2009,7, 46-51

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Switchable electrostatic interactions between gold nanoparticles and coiled coil peptides direct colloid assembly

S. C. Wagner, M. Roskamp, H. Cölfen, C. Böttcher, S. Schlecht and B. Koksch, Org. Biomol. Chem., 2009, 7, 46 DOI: 10.1039/B813429D

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