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Bcl-2 inhibits p53 nuclear import following DNA damage

Oncogene volume 15, pages 2767–2772 (1997)Cite this article

Abstract

Bcl-2 is an integral membrane oncoprotein that localizes to membranes of the mitochondria, endoplasmic reticulum, and nuclear envelope. Bcl-2 is a member of a family of cell death regulators and functions to inhibit apoptosis. Using confocal microscopy and immunoblotting we show that the ability of bcl-2 to suppress cell death following genotoxic damage can be a consequence of inhibiting nuclear import of induced wild-type p53 protein. Our data suggests that the ability of bcl-2 to modulate trafficking events is not cell type specific. These data support a `gatekeeper' mechanism for cell death suppression by bcl-2.

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Author notes

  1. Alexander Beham and Maria C Marin: AB and MCM contributed equally to this manuscript

Authors and Affiliations

  1. Department of Molecular Pathology, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd-Box 89, Houston, 77030, Texas, USA

    Alexander Beham, Maria C Marin, Antonio Fernandez, John Herrmann, Shawn Brisbay, Mona Sarkiss & Timothy J McDonnell

  2. Department of Immunobiology and Drug Carriers, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd-Box 89, Houston, 77030, Texas, USA

    Ana M Tari & Gabriel Lopez-Berestein

  3. Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd-Box 89, Houston, 77030, Texas, USA

    Guillermina Lozano

Authors
  1. Alexander Beham
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  2. Maria C Marin
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  3. Antonio Fernandez
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  4. John Herrmann
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  5. Shawn Brisbay
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  6. Ana M Tari
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  7. Gabriel Lopez-Berestein
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  8. Guillermina Lozano
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  9. Mona Sarkiss
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  10. Timothy J McDonnell
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Cite this article

Beham, A., Marin, M., Fernandez, A. et al. Bcl-2 inhibits p53 nuclear import following DNA damage. Oncogene 15, 2767–2772 (1997). https://doi.org/10.1038/sj.onc.1201464

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  • DOI: https://doi.org/10.1038/sj.onc.1201464

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