Abstract
Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.
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Acknowledgements
We thank several colleagues who made data available ahead of press. We gratefully acknowledge critical reading of this manuscript by I. Rubio, C. Liebmann, A. Östman, S. Hsieh and A. Uecker. Work in the authors' laboratories is supported by grants from the Deutsche Forschungsgemeinschaft, Human Frontiers in Science (to R.W.), the European Union (to R.W and F.D.B.) and Deutsche Krebshilfe (to F.D.B.).
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Wetzker, R., Böhmer, FD. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 4, 651–657 (2003). https://doi.org/10.1038/nrm1173
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DOI: https://doi.org/10.1038/nrm1173
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