Abstract
In January 2004, tiotropium bromide (Spiriva; Boehringer Ingelheim/Pfizer), an orally inhaled anticholinergic drug, was approved by the US FDA for the treatment of chronic obstructive pulmonary disease. Is it likely to become the bronchodilator of choice for this common and increasingly prevalent condition?
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References
Barnes, P. J. Chronic obstructive pulmonary disease. N. Engl. J. Med. 343, 269–280 (2000).
Lopez, A. D. & Murray, C. C. J. L. The global burden of disease, 1990–2020. Nature Med. 4, 1241–1243 (1998).
Barnes, P. J. New treatments for COPD. Nature Rev. Drug Discov. 1, 437–446 (2002).
Disse, B. et al. Ba 679 BR, a novel long-acting anti-cholinergic bronchodilator. Life Sci. 52, 537–544 (1993).
Barnes, P. J. et al. Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Life Sci. 56, 853–859 (1995).
Casaburi, R. et al. A long-term evaluation of once-daily inhaled tiotropium bromide in chronic obstructive pulmonary disease. Eur. Respir. J. 19, 217–224 (2002).
Vincken, W. et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur. Respir. J. 19, 209–216 (2002).
Donohue, J. F. et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 122, 47–55 (2002).
Brusasco, V. et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 58, 399–404 (2003).
FDA drug approvals list [online] (cited 10 June 2004) <http://www.fda.gov/cder/foi/label/2004/21395_spiriva_lbl.pdf> (2004).
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Mundy, C., Kirkpatrick, P. Tiotropium bromide. Nat Rev Drug Discov 3, 643–644 (2004). https://doi.org/10.1038/nrd1472
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DOI: https://doi.org/10.1038/nrd1472
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