Recent research expands our understanding of the biology of an important class of enzyme inhibitors.
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Rhipicephalus microplus serine protease inhibitor family: annotation, expression and functional characterisation assessment
Parasites & Vectors Open Access 07 January 2015
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References
Travis, J. & Salvesen, G.S. Human plasma proteinase inhibitors. Ann. Rev. Biochem. 52, 655–709 (1983).
Eitzman, D.T. et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J. Clin. Invest. 97, 232–237 (1996).
Romer, J. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med. 2, 287–292 (1996).
Kopf, M. et al. Impaired immune and acute phase responses in interleukin-6-deficient mice. Nature 369, 339–342 (1994)
Tanaka, M. et al. Fas ligand in human serum. Nature Med. 2, 317–322 (1996).
Enari, M., Talanian, R.V., Wong, W.W. & Nagata, S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723–726 (1996).
Kumar, S. & Harvey, N.L. Role of multiple cellular proteases in the execution of programmed cell death. FEBS Lett. 375, 169–173 (1995)
Mignatti, P. & Rifkin, D.B. Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev. 73, 161–195 (1993)
Wei, A., Rubin, H., Cooperman, B.S. & Christianson, D.W. Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop. Nature Struct. Biol. 1, 251–258 (1994).
Schreuder, H.A. et al. The intact and cleaved human antithrombin III complex as a model for serpin-protease interactions. Nature Struct. Biol. 1, 48–54 (1994).
Carrell, R.W., Stein, P.E., Fermi, G. & Wardell, M.R. Biological implications of a 3A structure of dimeric antithrombin. Nature Struct. Biol. 2, 257–270 (1994).
Lawrence, D.A. et al. Serpin-protease complexes are trapped as stable acyl-enzyme intermediates. J. Biol. Chem. 270, 25309–25312 (1995).
Wilczynska, M., Fa, M., Ohlsson, P-I. & Ny, T. The inhibition mechanism of serpins: evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex. J. Biol. Chem. 270, 29652–29655 (1995).
Plotnick, M.I., Mayne, L., Schechter, N.M. & Rubin, H. Distortion of the active site of chymotrypsin complexed with a serpin. Biochemistry (in the press).
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Rubin, H. Serine protease inhibitors (SERPINS): Where mechanism meets medicine. Nat Med 2, 632–633 (1996). https://doi.org/10.1038/nm0696-632
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DOI: https://doi.org/10.1038/nm0696-632
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