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At once harmful and beneficial: the dual properties of NF-κB

Nature Immunology volume 7, pages 901–902 (2006)Cite this article

Transcription factor NF-κB is key in both the injury and repair of damaged tissues. Astrocytes use the non-canonical NF-κB activation pathway to modulate brain inflammation in experimental autoimmune encephalomyelitis.

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Figure 1: Potential NF-κB signaling pathways in the central nervous system.

Kim Caesar

References

  1. Feldmann, M. & Steinman, L. Nature 435, 612–619 (2005).

    Article  CAS  Google Scholar 

  2. Lipton, S.A. Nat. Med. 3, 20–22 (1997).

    Article  CAS  Google Scholar 

  3. van Loo, G. et al. Nat. Immunol. 7, 954–961 (2006).

    Article  CAS  Google Scholar 

  4. Sen, R. & Baltimore, D. Cell 47, 921–928 (1986).

    Article  CAS  Google Scholar 

  5. Ghosh, S. & Karin, M. Cell 109, Suppl, S81–S96 (2002).

    Article  CAS  Google Scholar 

  6. Beinke, S. & Ley, S.C. Biochem. J. 382, 393–409 (2004).

    Article  CAS  Google Scholar 

  7. Sha, W.C. J. Exp. Med. 187, 143–146 (1998).

    Article  CAS  Google Scholar 

  8. Ishimaru, N., Kishimoto, H., Hayashi, Y. & Sprent, J. Nat. Immunol. 7, 763–772 (2006).

    Article  CAS  Google Scholar 

  9. Hilliard, B., Samoilova, E.B., Liu, T.S., Rostami, A. & Chen, Y. J. Immunol. 163, 2937–2943 (1999).

    CAS  PubMed  Google Scholar 

  10. Platten, M. & Steinman, L. Nat. Med. 11, 252–253 (2005).

    Article  CAS  Google Scholar 

  11. Lee, J.I. & Burckart, G. J. Clin. Pharmacol. 38, 981–993 (1998).

    Article  CAS  Google Scholar 

  12. Greenwood, J., Steinman, L. & Zamvil, S. Nat. Rev. Immunol. 6, 358–370 (2006).

    Article  CAS  Google Scholar 

  13. Joazeiro, C., Anderson, K. & Hunter, T. Cancer Res. 66, 1–3 (2006).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology and Neurological Sciences and the Interdepartmental Program in Immunology, Stanford University, Stanford, 94305, California, USA

    Sawsan Youssef & Lawrence Steinman

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  1. Sawsan Youssef
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  2. Lawrence Steinman
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Youssef, S., Steinman, L. At once harmful and beneficial: the dual properties of NF-κB. Nat Immunol 7, 901–902 (2006). https://doi.org/10.1038/ni0906-901

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