Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GM-CSF: the secret weapon in the TH17 arsenal

Identification of the pathogenic cytokines that underlie the IL-23-dependent disease progression of experimental autoimmune encephalomyelitis has proven elusive. Evidence now points to GM-CSF.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The central role of GM-CSF in TH17 cell–mediated inflammation in the CNS.

References

  1. El-Behi, M. et al. Nat. Immunol. 12, 568–575 (2011).

    Article  CAS  Google Scholar 

  2. Codarri, L. et al. Nat. Immunol. 12, 560–567 (2011).

    Article  CAS  Google Scholar 

  3. Langrish, C.L. et al. J. Exp. Med. 201, 233–240 (2005).

    Article  CAS  Google Scholar 

  4. Kroenke, M.A., Carlson, T.J., Andjelkovic, A.V. & Segal, B.M. J. Exp. Med. 205, 1535–1541 (2008).

    Article  CAS  Google Scholar 

  5. Sonderegger, I. et al. J. Exp. Med. 205, 2281–2294 (2008).

    Article  CAS  Google Scholar 

  6. McQualter, J.L. et al. J. Exp. Med. 194, 873–882 (2001).

    Article  CAS  Google Scholar 

  7. King, I.L., Kroenke, M.A. & Segal, B.M. J. Exp. Med. 207, 953–961 (2010).

    Article  CAS  Google Scholar 

  8. Ponomarev, E.D. et al. J. Immunol. 178, 39–48 (2007).

    Article  CAS  Google Scholar 

  9. McGeachy, M.J. et al. Nat. Immunol. 10, 314–324 (2009).

    Article  CAS  Google Scholar 

  10. Cua, D.J. & Tato, C.M. Nat. Rev. Immunol. 10, 479–489 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mandy J McGeachy.

Ethics declarations

Competing interests

The author declares competing financial interests: details accompany the full-text HTML version of the paper at http://www.nature.com/natureimmunology/.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McGeachy, M. GM-CSF: the secret weapon in the TH17 arsenal. Nat Immunol 12, 521–522 (2011). https://doi.org/10.1038/ni.2044

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2044

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing