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Rac signalling: a radical view

Nature Cell Biology volume 5, pages 185–187 (2003)Cite this article

GTP-binding proteins of the Rho family regulate each other's activities by largely elusive mechanisms. Now, an unexpected signalling pathway has been identified in fibroblasts that links Rac activation to the inhibition of Rho activity, through the release of oxygen radicals.

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Figure 1: Antagonism between Rho and Rac activities.
Figure 2: Inhibition of Rho activity by Rac signalling.

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  1. Centre for Molecular Microbiology and Infection & the Department of Biological Sciences, The Flowers Building, Room 2:41, Armstrong Road, Imperial College London, London, SW7 2AZ, UK

    Emmanuelle Caron

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  1. Emmanuelle Caron
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Caron, E. Rac signalling: a radical view. Nat Cell Biol 5, 185–187 (2003). https://doi.org/10.1038/ncb0303-185

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