Research ArticleThe nuclear receptor CAR modulates alcohol-induced liver injury
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Keywords
alcohol
alcohol dehydrogenase
aldehyde dehydrogenase
constitutive androstane receptor
liver injury
Cited by (0)
Xiaosong Chen and Zhipeng Meng: These authors contributed equally to this work.
The constitutive androstane receptor (CAR) is essential in xenobiotic detoxification. While CAR−/− mice are highly susceptible to alcohol-induced liver injury, pre-activation of CAR enhances the hepatic toxicity of alcohol in wild type but not CAR−/− mice. Drug-induced CAR activation thus enhances alcohol-induced liver injury by suppressing expression of enzymes that metabolize alcohol.
© 2011 United States & Canadian Academy of Pathology.