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Progress in cardiovascular biology: PPAR for the course

Nature Medicine volume 7, pages 23–24 (2001)Cite this article

Studies on mice lacking the peroxisome proliferator-activated receptor (PPAR) suggest that PPAR ligands reduce lipid accumulation in foamy macrophages, and may target other receptors. These findings warrant an in-depth investigation into the gene regulatory mechanisms of PPAR ligands, which are currently being developed as drugs to treat atherosclerosis and diabetes. (pages 41–47)

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Figure 1: Activation of PPAR-γ in foamy macrophages increases net lipid efflux.

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  1. Division of Endocrinology, Departments of Medicine and Genetics and The Penn Diabetes Center, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA

    Mitchell A. Lazar

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  1. Mitchell A. Lazar
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Lazar, M. Progress in cardiovascular biology: PPAR for the course. Nat Med 7, 23–24 (2001). https://doi.org/10.1038/83301

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