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Suppression of psychoactive effects of cocaine by active immunization

Nature volume 378, pages 727–730 (1995)Cite this article

Abstract

COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization1,2 to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.

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Authors and Affiliations

  1. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    M. Rocío A. Carrera & Loren H. Parsons

  2. Departments of Molecular Biology and Chemistry, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Jon A. Ashley, Peter Wirsching & Kim D. Janda

Authors
  1. M. Rocío A. Carrera
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  4. Peter Wirsching
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  5. George F. Koob
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  6. Kim D. Janda
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Carrera, M., Ashley, J., Parsons, L. et al. Suppression of psychoactive effects of cocaine by active immunization. Nature 378, 727–730 (1995). https://doi.org/10.1038/378727a0

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