Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Two components of long-term potentiation induced by different patterns of afferent activation

Nature volume 347, pages 477–479 (1990)Cite this article

Abstract

LONG-TERM potentiation (LTP) of excitatory synaptic transmission1–4 could be a mechanism underlying memory3,5. Induction of LTP requires Ca2+ influx into postsynaptic neurons6 through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA17,8 and dentate gyrus9) and neocortex10. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bliss, T. V. P. & Gardener-Medwin, A. R. J. Physiol. 232, 357–374 (1973).

    Article  CAS  Google Scholar 

  2. Bliss, T. V. P. & Lomo, T. J. Physiol. 232, 331–356 (1973).

    Article  CAS  Google Scholar 

  3. Teyler, T. J. & DiScenna, P. A. Rev. Neurosci. 10, 131–161 (1987).

    Article  CAS  Google Scholar 

  4. Kuba, K. & Kumamoto, E. Prog. Neurobiol. 34, 197–269 (1990).

    Article  CAS  Google Scholar 

  5. Teyler, T. J. & DiScenna, P. Brain Res. Rev. 7, 15–28 (1984).

    Article  Google Scholar 

  6. Lynch, G., Larson, J., Kelso, S., Barrionuevo, G. & Schottler, F. Nature 305, 719–721 (1983).

    Article  ADS  CAS  Google Scholar 

  7. Collingridge, G. L., Kehl, S. J. & McLennan, H. J. Physiol. 334, 33–46 (1983).

    Article  CAS  Google Scholar 

  8. Harris, E. W., Ganong, A. H. & Cotman, C. W. Brain Res. 323, 132–137 (1984).

    Article  CAS  Google Scholar 

  9. Morris, R. G. M., Anderson, E., Lynch, G. S. & Baudry, M. Nature 319, 774–776 (1986).

    Article  ADS  CAS  Google Scholar 

  10. Artola, A. & Singer, W. Nature 330, 649–652 (1987).

    Article  ADS  CAS  Google Scholar 

  11. Grover, L. M. & Teyler, T. J. Brain Res. 506, 53–61 (1990).

    Article  CAS  Google Scholar 

  12. Teyler, T. J. Brain Res. Bull. 5, 391–403 (1980).

    Article  ADS  CAS  Google Scholar 

  13. Harris, E. W. & Cotman, C. W. Neurosci. Lett. 70, 132–137 (1986).

    Article  CAS  Google Scholar 

  14. Cortes, R., Suparilai, M., Karobath, M. & Palacios, J. M. Neumsci. Lett. 42, 249–254 (1983).

    Article  CAS  Google Scholar 

  15. Regehr, W. G., Connor, J. A. & Tank, D. W. Nature 341, 533–537 (1989).

    Article  ADS  CAS  Google Scholar 

  16. Jones, R. S. G. & Heinemann, U. H. Brain Res. 416, 257–266 (1987).

    Article  CAS  Google Scholar 

  17. Middlemass, D. N. & Spedding, M. Nature 314, 94–96 (1985).

    Article  ADS  Google Scholar 

  18. Rane, S. G., Holtz, G. G. & Dunlap, K. Pflugers Arch. 409, 361–366 (1987).

    Article  CAS  Google Scholar 

  19. Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–497 (1982).

    Article  ADS  CAS  Google Scholar 

  20. Tsien, R. Y. Biochemistry 19, 2396–2404 (1980).

    Article  CAS  Google Scholar 

  21. Mulkeen, D., Anwyl, R. & Rowna, M. J. Neurosci. Lett. 80, 351–355 (1987).

    Article  CAS  Google Scholar 

  22. Taube, J. S. & Schwartzkroin, P. A. Brain Res. 379, 275–285 (1986).

    Article  CAS  Google Scholar 

  23. Mayer, M. L. & Westbrook, G. L. J. Physiol. 354, 29–53 (1984).

    Article  CAS  Google Scholar 

  24. Nowak, L., Bregestovski, P., Ascher, P., Herbet, A. & Prochiantz, A. Nature 307, 462–465 (1984).

    Article  ADS  CAS  Google Scholar 

  25. Madison, D. V. & Nicoll, R. A. J. Physiol. 354, 319–331 (1984).

    Article  CAS  Google Scholar 

  26. Lancaster, B. & Nicoll, R. A. J. Physiol. 389, 187–203 (1987).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, 44272, USA

    Lawrence M. Grover & Timothy J. Teyler

Authors
  1. Lawrence M. Grover
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Timothy J. Teyler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grover, L., Teyler, T. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347, 477–479 (1990). https://doi.org/10.1038/347477a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/347477a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing