Abstract
Alternative splicing of RNA transcripts from the calcitonin gene produces mRNAs that encode different polypeptides1. While the mRNA encoding calcitonin predominates in thyroidal ‘C’ cells, calcitonin gene-related peptide (CGRP) mRNA appears to be the major mRNA component in non-thyroid tissue, including brain1. The predicted peptide arising from translation of CGRP mRNA has now been identified immunocytochemically throughout the central and peripheral nervous systems2. CGRP, a 37-residue peptide, is distributed in brain pathways subserving sensory, motor and autonomic functions. We report here that CGRP acts in the central nervous system to stimulate selectively noradrenergic sympathetic outflow.
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Fisher, L., Kikkawa, D., Rivier, J. et al. Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 305, 534–536 (1983). https://doi.org/10.1038/305534a0
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DOI: https://doi.org/10.1038/305534a0
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