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Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

Nature volume 299, pages 793–797 (1982)Cite this article

Abstract

DNA sequences complementary to the Torpedo californica electroplax mRNA coding for the α-subunit precursor of the acetylcholine receptor were cloned. The nucleotide sequence of the cloned cDNA indicates that the precursor consists of 461 amino acids including a prepeptide of 24 amino acids. Possible sites for acetylcholine binding and antigenic determinants on the α-subunit molecule are discussed.

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Authors and Affiliations

  1. Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Masaharu Noda, Hideo Takahashi, Tsutomu Tanabe, Mitsuyoshi Toyosato, Yasuji Furutani & Shosaku Numa

  2. Pharmaceutical Institute, Keio University School of Medicine, Tokyo, 160, Japan

    Tadaaki Hirose, Michiko Asai & Seiichi Inayama

  3. Department of Biology, Kyushu University Faculty of Science, Fukuoka, 812, Japan

    Takashi Miyata

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  1. Masaharu Noda
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  2. Hideo Takahashi
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  4. Mitsuyoshi Toyosato
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Noda, M., Takahashi, H., Tanabe, T. et al. Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299, 793–797 (1982). https://doi.org/10.1038/299793a0

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