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Evidence for dopamine receptors mediating sedation in the mouse brain

Abstract

APOMORPHINE, a direct stimulant of dopamine (DA) receptors, and L-dopa, the direct precursor of DA, have a biphasic action on behaviour; in low doses they decrease motor activity, while in higher doses they cause hyper-motility and sterotypy1–3.

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References

  1. Strömberg, U., and Svensson, T. H., Naunyn-Schmiedeberg's Arch. Pharmac., 287, 171–179 (1975).

    Article  Google Scholar 

  2. Strömbom, U., Naunyn-Schmiedeberg's Arch. Pharmac., 292, 167–176 (1976).

    Article  Google Scholar 

  3. Carlsson, A., in Pre- and Postsynaptic Receptors (edit. by Usdin, E., and Bunney, W. E., Jr), 49–63 (Dekker, New York, 1975).

    Google Scholar 

  4. Kelly, P. H., Seviour, P. W., and Iversen, S. D., Brain Res., 94, 507–522 (1975).

    Article  CAS  Google Scholar 

  5. Roberts, D. C. S., Zis, A. P., and Fibiger, H. C., Brain Res., 93, 441–454 (1975).

    Article  CAS  Google Scholar 

  6. Bunney, B. S., and Aghajanian, G. K., in Pre- and Postsynaptic Receptors (edit. by Usdin, E., and Bunney, W. E., Jr), 89–120 (Dekker, New York, 1975).

    Google Scholar 

  7. Groves, P. M., Wilson, C. J., Young, S. J., and Rebec, G. V., Science, 190, 522–529 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Kehr, W., Carlsson, A., and Lindqvist, M., in Advances in Neurology, 91 (edit. by Calne, D. B., Chase, T. N., and Barbeau, A.), 185–195 (Raven, New York, 1975).

    Google Scholar 

  9. Sharman, D. F., Brit. med. Bull., 20, 110 (1973).

    Article  Google Scholar 

  10. Roth, R. H., Murrin, L. C., and Walters, J. R., Eur. J. Pharmac., 36, 163–171 (1976).

    Article  CAS  Google Scholar 

  11. Clement Cormier, Y. C., Kebabian, J. W., Petzold, G. L., and Greengard, P., Proc. natn. Acad. Sci. U.S.A., 71, 1113–1117 (1974).

    Article  ADS  CAS  Google Scholar 

  12. Van Rossum, J. M., in Neuropsychopharmacology (edit. by Brill, H.), 321 (Excerpta Medica Foundation, Amsterdam, 1967).

    Google Scholar 

  13. Creese, I., Burt, D. R., and Snyder, S. H., Science, 192, 481–483 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Cools, A. R., Struyker Boudier, H. A. J., and van Rossum, J. M., Eur. J. Pharmac., 37, 283–293 (1976).

    Article  CAS  Google Scholar 

  15. Langer, S. Z., Biochem. Pharmac., 23, 1793–1800 (1974).

    Article  CAS  Google Scholar 

  16. Spano, P. F., Di Chiara, G., Tonon, G. C., and Trabucchi, M., J. Neurochem. 27, 1565–1568 (1976).

    Article  CAS  Google Scholar 

  17. Phillipson, O. T., and Horn, A. S., Nature, 261, 418–420 (1976).

    Article  ADS  CAS  Google Scholar 

  18. Geffen, L. B., Jessell, T. M., Cuello, A. C., and Iversen, L. L., Nature, 260, 258–260 (1976).

    Article  ADS  CAS  Google Scholar 

  19. Mantel, N., and Valand, R. S., Biometrics, 26, 547–558 (1970).

    Article  CAS  Google Scholar 

Download references

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DI CHIARA, G., PORCEDDU, M., VARGIU, L. et al. Evidence for dopamine receptors mediating sedation in the mouse brain. Nature 264, 564–567 (1976). https://doi.org/10.1038/264564a0

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