Abstract
RADIOLABELLED γ-aminobutyric acid (GABA) is taken up by both neurones and glial cells in the central nervous system1,2, where it mixes with endogenous GABA stores3. Superior cervical and dorsal root ganglia also accumulate radioactive GABA and this amino acid is taken up exclusively in satellite glial cells4,5. The presence of GABA in peripheral neural tissues has not, however, been demonstrated unequivocally6–8. We have measured GABA and glutamic acid in rat superior cervical and nodose ganglia by mass fragmentography. The concentration of GABA in nodose ganglia was lower than in the superior cervical sympathetic ganglion (SCG). Moreover, our results suggest that the content of GABA in the SCG may be controlled by neuronal activity.
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BERTILSSON, L., SURIA, A. & COSTA, E. γ-Aminobutyric acid in rat superior cervical ganglion. Nature 260, 540–541 (1976). https://doi.org/10.1038/260540a0
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DOI: https://doi.org/10.1038/260540a0
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