Abstract
DOPAMINERGIC systems in various parts of the mammalian brain, particularly in striatal, mesolimbic, mesocortical and hypothalamic structures, are involved in the control of motor activity, autonomic processes and emotional behaviour. An altered dopaminergic transmission in striatum seems to be responsible for Parkinsonism, whereas abnormalities in other, still poorly defined, dopaminergic synapses could participate in the aetiology of schizophrenia1–3. Thus, there is considerable theoretical as well as therapeutical interest in defining specific characteristics of different dopaminergic systems participating in the control of these various functions.
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References
Hornykewicz, O., Pharmac. Rev., 18, 925 (1966).
Matthysse, S., in The Neurosciences, third Study Program, (edit. by Schmitt, F. V., and Norden, F. G.), 733–737 (MIT Press, Cambridge, Massachusetts, 1974).
Snyder, S. H., ibid 721–732.
Ungerstedt, U., ibid 979–988.
Tarsy, D., and Baldessarini, R. J., Nature new Biol., 245, 262 (1973).
Gianutsos, G., Drawbaugh, R. B., Hynes, M. D., and Lal, H., Life Sci., 14, 887 (1974).
von Voigtlander, P. F., Losey, F. G., and Triezenberg, A. J., J. Pharmac. exp. Ther., 193, 88 (1975).
Ghiel, H., Yehuda, S., and Wurtman, R. J., Life Sci., 14, 483 (1974).
Miller, L. C., and Tainter, M. L., Proc. Soc. exp. Biol. Med., 57, 261 (1944).
Gouret, C., J. Pharmac., 4, 341 (1973).
Creese, I., and Iversen, S., Brain Res., 83, 419 (1975).
Iversen, L. L., Science, 188, 1084 (1975).
Yehuda, S., and Wurtman, R. J., Eur. J. Pharmac., 30, 154 (1975).
Bjorklund, O., Lindvall, O., and Nobin, A., Brain Res., 89, 29 (1975).
Martres, M. P., Baudry, M., and Schwartz, J. C., Nature, 253, 362–363 (1975).
Dismukes, K., and Daly, J. W., Molec. Pharmac., 10, 933–940 (1974).
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COSTENTIN, J., PROTAIS, P. & SCHWARTZ, J. Rapid and dissociated changes in sensitivities of different dopamine receptors in mouse brain. Nature 257, 405–407 (1975). https://doi.org/10.1038/257405a0
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DOI: https://doi.org/10.1038/257405a0
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