Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation

Abstract

THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ball, G., Brereton, G. G., Fulwood, M., Ireland, D. M., and Yates, P., Biochem. J., 120, 709–718 (1970).

    Article  CAS  Google Scholar 

  2. Mills, D. C. B., and Smith, J. B., Biochem. J., 121, 185–196 (1971).

    Article  CAS  Google Scholar 

  3. Kloeze, J., in Prostaglandins (edit. by Bergstrom, S. and Samuelsson, B.) 241–252 (Almquist and Wiksell, Stockholm, 1967).

    Google Scholar 

  4. Salzman, E. W., New Engl. J. Med., 286, 358–363 (1972).

    Article  CAS  Google Scholar 

  5. Smith, J. B., and Willis, A. L., Nature new Biol., 231, 235–237 (1971).

    Article  CAS  Google Scholar 

  6. Droller, M. J., Proc. 15th Mtg Am. Soc. Hematol. (1972).

  7. Born, G. V. R., J. Physiol., Lond., 162, 67P–68P (1962).

    Google Scholar 

  8. Hirsh, J., Street, D., Cade, J. F., and Amy, H., Blood, 41, 369–377 (1973).

    CAS  PubMed  Google Scholar 

  9. Haslam, R. J., Nature, 202, 765–768 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Wolfe, S. M., and Shulman, N. R., Biochem. biophys. Res. Commun., 35, 265–272 (1969).

    Article  CAS  Google Scholar 

  11. White, A. A., and Zenser, T. V., Analyt. Biochem., 41, 372–396 (1971).

    Article  CAS  Google Scholar 

  12. Ramachandran, J., Analyt. Biochem., 43, 227–239 (1971).

    Article  CAS  Google Scholar 

  13. Droller, M. J., and Wolfe, S. M., J. clin. Invest., 51, 3094–3103 (1972).

    Article  CAS  Google Scholar 

  14. Shio, H., and Ramwell, P. W., Nature new Biol., 236, 45–46 (1972).

    Article  CAS  Google Scholar 

  15. Droller, M. J., and Wolfe, S. M., New Engl. J. Med., 286, 948 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRUNO, J., TAYLOR, L. & DROLLER, M. Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation. Nature 251, 721–723 (1974). https://doi.org/10.1038/251721a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/251721a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing