Abstract
CLASSIFICATION of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators. Ahlquist1–3 has suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems. Our investigations have provided results which cannot be explained easily on the assumption that the β-type designates a single receptor population4–6. We now report additional studies which show that two distinct receptor types are at present included within this group.
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References
Ahlquist, R. P., Amer. J. Physiol., 154, 586 (1948).
Ahlquist, R. P., Arch. Intern. Pharmacodyn., 139, 38 (1962).
Ahlquist, R. P., J. Pharm. Sci., 55, 359 (1966).
Lands, A. M., and Brown, T. G., jun., Proc. Soc. Exp. Biol. and Med., 116, 331 (1964).
Lands, A. M., Groblewski, G. E., and Brown, T. G., jun., Arch. Intern. Pharmacodyn., 161, 68 (1966).
Arnold, A., McAuliff, J. P., Luduena, F. P., Brown, T. G., jun., and Lands, A. M., Fed. Proc., 25, 500 (1966).
v. Handel, E., and Zilversmit, D. B., J. Lab. Clin. Med., 50, 152 (1957).
Černohorsky, M., Čepelik, J., Lincová, D., and Wenke, M., J. Pharm Pharmacol., 18, 188 (1966); ibid., 18, 190 (1966).
Brown, T. G., jun., and Lands, A. M., in Evaluation of Drug Activities: Pharmacometrics (edit. by Lawrence, D. R., and Bacharach, A. L.), 1, 353 (Academic Press, London and New York, 1964).
Luduena, F. P., Miller, E., and Wilt, W. A., J. Amer. Pharm. Assoc. (Sc. Ed.), 44, 363 (1955).
Brown, T. G., jun., and Green, T. J., Amer. Heart. J., 63, 545 (1962).
Pratesi, P., Grana, E., Lilla, L., LaManna, A., and Villa, L., Il Farmaco—Ed. Sc., 18, 920, (1963).
Mueller, P. S., and Horwitz, D., J. Lipid Res., 3, 251 (1962).
v. Rossum, J. M., J. Pharm. Pharmacol., 17, 202 (1965).
Lands, A. M., and Brown, T. G., jun., Chemical Constitution and Pharmacodynamic Action (edit. by Burger, A.), 1 (Marcel Dekker, Inc., New York, in the press).
Moran, N. C., and Perkins, M. E., J. Pharmacol. Exp. Therap., 124, 223 (1958).
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LANDS, A., ARNOLD, A., MCAULIFF, J. et al. Differentiation of Receptor Systems activated by Sympathomimetic Amines. Nature 214, 597–598 (1967). https://doi.org/10.1038/214597a0
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DOI: https://doi.org/10.1038/214597a0
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