Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Simple Allosteric Model for Membrane Pumps

Abstract

THE list of plausible hypothetical schemes which have been advanced to account for active transport is so long that any hope of extending it might appear unwarranted. However, very few specific molecular mechanisms have been considered. It therefore appears timely to point out that transport contingent on a chemical reaction can be understood in terms of a very simple molecular model, for which a noteworthy precedent can be found among recent crystal structure determinations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Glynn, I. M., Prog. Biophys. Biophys. Chem., 8, 241 (1957).

    Article  CAS  PubMed  Google Scholar 

  2. Burgen, A. S. V., Canad. J. Biochem. Physiol., 35, 569 (1957).

    Article  CAS  PubMed  Google Scholar 

  3. Post, R. L., Sen, A. K., and Rosenthal, A. S., J. Biol. Chem., 240, 1437 (1965).

    CAS  PubMed  Google Scholar 

  4. Mitchell, P., Biochem. Soc. Symp., 16, 73 (1959).

    CAS  PubMed  Google Scholar 

  5. Mitchell, P., Biochem. Soc. Symp., 22, 142 (1963).

    Google Scholar 

  6. Jarnefelt, J., Biochim. Biophys. Acta, 59, 643 (1962).

    Article  CAS  PubMed  Google Scholar 

  7. Albers, R. W., Fahn, S., and Koval, G. J., Proc. U.S. Nat. Acad. Sci., 50, 474 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Ussing, H. H., cited in Czaky, T. Z., Ann. Rev. Physiol., 27, 415 (1965).

    Article  Google Scholar 

  9. Muirhead, H., and Perutz, M. F., Nature, 199, 633 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Sen, A. K., and Post, R. L., J. Biol. Chem., 239, 345 (1964).

    CAS  PubMed  Google Scholar 

  11. Davson, H., and Danielli, J. F., The Permeability of Natural Membranes, (Cambridge University Press, 1952).

    Google Scholar 

  12. Jardetzky, O., and Snell, F. M., Proc. U.S. Nat. Acad. Sci., 46, 616 (1960).

    Article  ADS  MathSciNet  CAS  Google Scholar 

  13. Katchalsky, A., and Kedem, O., Biophys. J., Suppl., 2, 73 (1962).

    Article  Google Scholar 

  14. Cohen, G. N., and Monod, J., Bact. Rev., 21, 169 (1957).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JARDETZKY, O. Simple Allosteric Model for Membrane Pumps. Nature 211, 969–970 (1966). https://doi.org/10.1038/211969a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/211969a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing