Abstract
Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.
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REFERENCES
J. A. H. Hughes, T. W. Smith, H. W. Kosterlitz, L. A. Fothergill, B. Morgan, and H. R. Morris. Nature 255:577–579 (1975).
R. S. Rapaka. In R. S. Rapaka, G. Barnett, and R. L. Hawks (eds.), Opioid Peptides: Medicinal Chemistry, NIDA Research Monograph 69, U.S. Government Printing Office, Washington, D.C., 1986, pp. 3–20.
R. A. Frederickson. In R. S. Rapaka and R. L. Hawks (eds.), Opioid Peptides: Molecular Pharmacology, Biosynthesis, and Analysis, NIDA Research Monograph 70, U.S. Government Printing Office, Washington, D.C., 1986, pp. 367–384.
R. C. A. Frederickson, C. J. Parli, G. W. DeVane, and M. D. Hynes. In L. S. Harris (ed.), NIDA Research Monograph 43, U.S. Government Printing Office, Washington, D.C., 1982, pp. 150–156.
R. D. Russell and K.-J. Chang. Pain 36:381–389 (1989).
J. A. H. Lord, A. A. Waterfield, J. Hughes, and H. W. Kosterlitz. Nature (London) 267:495–499 (1979).
K. J. Chang and P. Cuatrecasas. J. Biol. Chem. 254:2610–2618 (1979).
J. M. Hambrook, B. A. Morgan, M. J. Rance, and C. F. C. Smith. Nature 262:782–783 (1976).
P. E. Hansen and B. A. Morgan. In S. Uenfriend and J. Meienhofer (eds.), The Peptides: Analysis, Synthesis and Biology, Vol. 6, Academic Press, New York, 1984, pp. 269–321.
J. S. Morley. Annu. Rev. Pharmacol. Toxicol. 20:81–100 (1980).
J. S. Morley. Br. Med. Bull. 39:5–10 (1983).
R. S. Rapaka. Life Sci. 39:1825–1843 (1986).
R. S. Rapaka, B. N. Dhawan, and V. Renugopalakrishnan. In R. S. Rapaka and B. N. Dhawan (eds.), Opioid Peptides: An Update, NIDA Research Monograph 70, U.S. Government Printing Office, Washington, D.C., 1986. pp. 217–232.
V. J. Hruby. Life Sci. 31:189–199 (1982).
P. W. Schiller. In R. S. Rapaka, G. Barnett, and R. L. Hawks (eds.), Opioid Peptides: Medicinal Chemistry, NIDA Research Monograph 69, U.S. Government Printing Office, Washington, D.C., 1986, pp. 291–311.
H. I. Mosberg, R. Hurst, V. J. Hruby, K. Gee, H. I. Yamamura, J. J. Galligan, and T. F. Burks. Proc. Natl. Acad. Sci. USA 80:5871–5874 (1983).
R. Cotton, M. G. Giles, L. Miller, J. S. Shaw, and D. Timms. Eur. J. Pharmacol. 97:331–332 (1984).
J. J. Galligan, H. I. Mosberg, R. Hurst, V. J. Hruby, and T. F. Burks. J. Pharmacol. Exp. Ther. 229:641–648 (1984).
F. Porreca, H. I. Mosberg, R. Hurst, V. J. Hruby, and T. F. Burks. J. Pharmacol. Exp. Ther. 230:341–348 (1984).
A. Cowan, X.-Z. Zhe, and F. Porreca. Neuropeptides 5:311–314 (1985).
S. J. Ward, P. S. Portoghese, and A. E. Takemori. J. Pharmacol. Exp. Ther. 220:494–498 (1982).
E. F. Hahn, M. Carroll-Buatti, and G. W. Pasternak. J. Neurosci. 5:572–576 (1982).
G. S. F. Ling and G. W. Pasternak. Brain Res. 271:152–156 (1983).
G. S. F. Ling, S. Ronit, J. A. Clark, and G. W. Pasternak. Eur. J. Pharmacol. 129:33–38 (1986).
I. F. James and A. Goldstein. Mol. Pharmacol. 25:337–342 (1985).
A. Goldstein and I. F. James. Mol. Pharmacol. 25:343–348 (1984).
A. D. Corbett, M. G. C. Gillan, H. W. Kosterlitz, A. T. McKnight, and S. J. Paterson. Br. J. Pharmacol. 80:669 (1983).
K. Oka, J. D. Kantrowitz, and S. Spector. Proc. Natl. Acad. Sci. USA 82:1852–1854 (1985).
F. Porreca, J. S. Heyman, H. I. Mosberg, J. R. Omnaas, and J. L. Vaught. J. Pharmacol. Exp. Ther. 241:393–40 (1987).
B. K. Handa, A. C. Lane, J. A. H. Lord, B. A. Morgan, M. J. Rance, and C. F. C. Smith. Eur. J. Pharmacol. 70:531–540 (1981).
J. S. Heyman, S. A. Mulvaney, H. I. Mosberg, and F. Porreca. Brain Res. 420:100–108 (1987).
A. E. Takemori and P. S. Portoghese. J. Pharmacol. Exp. Ther. 243:91–94 (1987).
A. E. Takemori, B. Y. Ho, J. S. Naeseth, and P. S. Portoghese. J. Pharmacol. Exp. Ther. 246:255–258 (1988).
J. A. Clark, Y. Itzhak, V. J. Hruby, H. I. Yamamura, and G. W. Pasternak. Eur. J. Pharmacol. 128:303–304 (1986).
J. S. Heyman, C. L. Williams, T. F. Burks, H. I. Mosberg, and F. Porreca. J. Pharmacol. Exp. Ther. 245:238–243 (1988).
F. Porreca, J. S. Heyman, H. I. Mosberg, J. R. Omnaas, and J. L. Vaught. J. Pharmacol. Exp. Ther. 241:341–348 (1984).
A. S. Moskowitz and R. R. Goodman. Brain Res. 360:108–116 (1985).
J. R. Mathiasen, R. B. Raffa, and J. L. Vaught. Life Sci. 40:1989–1994 (1987).
T. S. Jensen and T. L. Yaksh. Brain Res. 372:301–312 (1986).
B. M. Onofrio and T. L. Yaksh. Lancet X:1386–1387 (1983).
T. L. Yaksh and T. A. Rudy. Physiol. Behav. 17:1031–1036 (1976).
T. L. Yaksh, T. M. Jessell, R. Gamse, A. W. Mudge, and S. E. Leeman. Nature 286:155–157 (1980).
J. S. Heyman, J. L. Vaught, H. I. Mosberg, R. C. Haaseth, and F. Porreca. Eur. J. Pharmacol. 165:1–10 (1989).
J. S. Heyman, Q. Jiang, R. B. Rothman, H. I. Mosberg, and F. Porreca. Eur. J Pharmacol. 169:43–52 (1989).
F. Porreca and T. F. Burks. J. Pharmacol. Exp. Ther. 227:22–27 (1983).
Y. Shimohigashi, T. Costa, A. Pfeiffer, A. Herz, H. Kimura, and C. H. Stammer. FEBS Lett. 222:71–74 (1987).
Y. Shimohigashi, Y. Takano, H. Kamiya, T. Costa, A. Herz, and C. H. Stammer. FEBS Lett. 223:289–293 (1988).
J. Magnan and M. Tiberi. Dev. Brain Res. 45:275–281 (1989).
A. Cowan, X. Z. Zhe, H. I. Mosberg, J. R. Omnaas, and F. Porreca. J. Pharmacol. Exp. Ther. 246:950–955 (1988).
E. T. Wei and H. H. Loh. Science 193:1262–1263 (1976).
E. T. Wei. J. Pharmacol. Exp. Ther. 216:12–18 (1983).
K. J. Chang, P. Cuatrecasas, E. T. Wei, and J. K. Chang. Life Sci. 30:1547–1551 (1982).
J. W. Holaday, J. B. Long, and F. C. Tortella. Fed. Proc. 44:2860–2862 (1985).
J. W. Holaday, F. C. Tortella, R. Maneckjee, and J. B. Long. NIDA Res. Monogr. 71:173–188 (1986).
J. L. Vaught and A. E. Takemori. J. Pharmacol. Exp. Ther. 208:86–90 (1979).
N. M. Lee, L. Leybin, J. K. Chang, and H. H. Loh. Eur. J. Pharmacol. 68:181–185 (1980).
J. L. Vaught, R. B. Rothman, and T. C. Westfall. Life Sci. 30:1443–1455 (1982).
R. B. Rothman and T. C. Westfall. Mol. Pharmacol. 21:538–547 (1982).
R. B. Rothman and T. C. Westfall. Mol. Pharmacol. 21:548–557 (1982).
C. D. Demoliou-Mason and E. A. Barnard. J. Neurosci. 46:1118–1128 (1986).
R. B. Rothman, A. E. Jacobson, K. C. Rice, and M. Herkenham. Peptides 8:1015–1021 (1987a).
R. B. Rothman, S. McLean, V. Bykov, R. A. Lessor, A. E. Jacobson, K. C. Rice, and J. W. Holaday. Eur. J. Pharmacol. 142:73–81 (1987).
R. W. Barrett and J. L. Vaught. Eur. J Pharmacol. 80:427–430 (1982).
R. W. Barrett and J. L. Vaught. Life Sci. 33:2439–2448 (1983).
J. W. Holaday and R. J. D'amato. Life Sci. 33:703–706 (1983).
R. J. D'amato and J. W. Holaday. Proc. Natl. Acad. Sci. USA 81:2892–2901 (1984).
R. J. Sheldon, L. Nunan, and F. Porreca. J. Pharmacol. Exp. Ther. 249:462–469 (1989).
W. D. Bowen, S. Gentleman, M. Herkenham, and C. Pert. Proc. Natl. Acad. Sci USA 78:4818–4822 (1981).
G. W. Pasternak, S. R. Childers, and S. H. Snyder. Science 208:514–516 (1986).
R. B. Rothman, J. B. Long, V. Bykov, A. E. Jacobson, K. C. Rice, and J. W. Holaday. J. Pharmacol. Exp. Ther. 247:405–416 (1988).
R. D. Russell, J. B. Leslie, Y.-F. Su, W. D. Watkins, and K.-J. Chang. NIDA Res. Monogr. 75:97–100 (1986).
C. Stein, M. J. Millan, T. S. Shippenburg, K. Peter, and A. Herz. J. Pharmacol. Exp. Ther. 248:1269–1275 (1989).
P. W. Schiller and J. DiMaio. In V. J. Hrugy and D. H. Rich (eds.), Peptides: Structure and Function, Pierce Chemical Co., Rockford, IL, 1983, pp. 269–278.
V. J. Hruby. In R. S. Rapaka, G. Barnett, and R. L. Hawks (eds.), Opioid Peptides: Medicinal Chemistry, NIDA Research Monograph 69, U.S. Government Printing Office, Washington, D.C., 1986, pp. 128–147.
P. W. Schiller. In S. Udenfriend and J. Meienhofer (eds.), The Peptides: Synthesis, Analysis, and Biology, Vol. 6, Academic Press, New York, pp. 219–268.
B. P. Roques, M. C. Fournie-Zaluski, G. Gacel, M. David, J. C. Meunier, B. Maigret, and J. L. Morgat. In E. Costa and M. Trabucchi (eds.), Regulatory Peptides: From Molecular Biology to Function, Raven Press, New York, 1982; pp. 321–331.
J.-M. Zajac, G. Gacel, F. Petit, P. Dodey, P. Rossiognol, and B. P. Roques. Biochem. Biophys. Res. Commun. 111:390–397 (1983).
P. Delay-Goyet, C. Seguin, G. Geisel, and B. P. Roques. J. Biol. Chem. 263:4124–4130 (1988).
J. DiMaio and P. W. Schiller. Proc. Natl. Acad. Sci USA 77:7162–7166 (1980).
P. W. Schiller, T. M. D. Nguyen, L. Maziak, and C. A. Lemieux. Biochem. Biophys. Res. Commun. 127:558–564 (1985).
P. W. Schiller, T. M.-D. Nguyen, N. N. Chung, and C. Lemieux. J. Med. Chem. 32:698–703 (1989).
G. Toth, T. H. Kramer, R. Knapp, G. Lui, P. Davis, T. F. Burks, H. I. Yamamura, and V. J. Hruby. J. Med. Chem. 33:249–252 (1990).
M. Goodman and M. Chorev. Accounts Chem Res. 12:1–7 (1979).
J. M. Berman, M. Goodman, T. M. D. Nguyen, and P. W. Schiller. Biochem. Biophys. Res. Commun. 115:864–870 (1983).
S. Salvadori, M. Marastoni, G. Balboni, G. Sarto, and R. Tomatis. Int. J. Peptide Protein Res. 21:526–533 (1985).
L. H. Lazarus, W. E. Wilson, R. de Castiglione, and A. Guglietta. J. Biol. Chem. 264:3047–3050 (1989).
G. Kreil, D. Barra, M. Simmaco, V. Eraspamer, G. F. Eraspamer, L. Negri, C. Severini, R. Corsi, and P. Melchiorri. Eur. J. Pharmacol. 162:123–128 (1989).
V. Eraspamer, P. Melchiorri, G. Falconieri-Eraspamer, L. Negri, R. Corsi, C. Severini, D. Barra, M. Simmaco, and G. Kreil. Proc. Natl. Acad. Sci. USA 86:5188–5192 (1989).
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Rapaka, R.S., Porreca, F. Development of Delta Opioid Peptides as Nonaddicting Analgesics. Pharm Res 8, 1–8 (1991). https://doi.org/10.1023/A:1015809702296
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DOI: https://doi.org/10.1023/A:1015809702296