Review ArticleMolecular Determinants of Recognition for the Intestinal Peptide Carrier
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2005, Annual Reports in Computational ChemistryCitation Excerpt :Of the active transporters identified to date, most attention has been focused on Peptide Transporter 1 (PepT1), a member of the proton-coupled, oligopeptide transporter (POT) family [48]. Initial modeling work on PepT1 substrates was carried out by Swaan et al.[49,50] and Bailey et al.[51]. More recently, Gebauer et al.[52] developed CoMFA and CoMSIA models from a set of 79 dipeptide PepT1 substrates for which affinity data had been generated under consistent conditions.
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2004, Journal of Pharmaceutical SciencesCitation Excerpt :When the PLS matrices consisting of 4 principal components, calculated based on the entire data set, were expanded to a linear equation, the following equation was obtained: It has been known that cefazolin, cefoperazone, cefoxitin, and cefotiam do not interact with peptide transporters.32 For these compounds, the uptake rate that was estimated using eq. (2) was very low (0.076, 0.028, 0.14, and 0.10 nmol/cm2/2 h, respectively).