Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug
Section snippets
Acknowledgements
This work was supported, in part, by Grants-in-aid for Research on Pharmaceutical and Medical Safety, for Brain Science, and for Comprehensive Research on Aging and Health from the Japanese Ministry of Health, Labour and Welfare, and by Grants-in-aid for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, Science and Technology. We would like to thank Dr Jean Lud Cadet, Molecular Neuropsychiatry Branch, NIH/NIDA/Intramural Research Program, USA for reviewing the
References (17)
- et al.
Non-steroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene
Biochem. Biophys. Res. Commun.
(1995) - et al.
Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice
Mol. Brain Res.
(1998) - et al.
Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice
Neuroscience
(1998) - et al.
Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice
Neurosci. Lett.
(2002) - et al.
Free radicals and the pathobiology of brain dopamine systems
Neurochem. Int.
(1998) - et al.
Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro
Int. J. Immunopharmacol.
(1999) - et al.
Autoradiographic evidence for methamphetamine induced striatal dopaminergic loss in mouse brain: attenuation in CuZn-superoxide dismutase transgenic mice
Brain Res.
(1996) - et al.
Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice
Neuropharmacology
(2000)
Cited by (75)
Chronic exposure to methadone impairs memory, induces microgliosis, astrogliosis and neuroinflammation in the hippocampus of adult male rats
2022, Journal of Chemical NeuroanatomyCombined and sequential effects of alcohol and methamphetamine in animal models
2021, Neuroscience and Biobehavioral ReviewsNeurotoxicity of methamphetamine: Main effects and mechanisms
2021, Experimental NeurologyCitation Excerpt :METH also causes microglial activation in various brain regions (Gonçalves et al., 2017; Gou et al., 2020; Sekine et al., 2008; Thomas et al., 2004, 2009). A role for microglial in the appearance of METH neurotoxicity is supported by reports that drugs such as MK-801 and dextromethorphan that block microglial activation can protect against the toxic effects of the drug (Asanuma et al., 2003; Thomas and Kuhn, 2005). The sigma-1 receptor may also participate in mediating METH neurotoxicity via their effects on glial activation.
Methamphetamine and its immune-modulating effects
2019, Maturitas