Research ArticleKinetics of the bile acid transporter and hepatitis B virus receptor Na+/taurocholate cotransporting polypeptide (NTCP) in hepatocytes
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Abbreviations
HBV
hepatitis B virus
WMHBV
woolly monkey hepatitis B virus
WHV
woodchuck hepatitis B virus
myr-preS1
N-terminal myristoylated and C-terminal strep-tagged preS1-lipopeptide from N-terminal amino acids 2-48 of the large surface protein of the respective HBV
myr-preS1-AX594
N-terminal myristoylated and C-terminal fluorescently labelled with dye Alexa594 from N-terminal amino acids 2-48 of the large surface protein of HBV
NTCP
Na+/taurocholate cotransporting polypeptide
SLC
solute carrier
ASBT
apical sodium-dependent bile acid transporter
SOAT
sodium-dependent organic anion transporter
DHEAS
dehydroepiandrosterone sulfate
TMD
transmembrane domain
TBHBV
tent-making bat HBV
PTH
primary Tupaia belangeri hepatocytes
PHH
primary human hepatocytes
HDV
hepatitis D virus
tNtcp
Tupaia belangeri Ntcp
HEK293
human embryonic kidney 293 cells
HepG2
human hepatocellular liver carcinoma cell line
DMEM
Dulbecco’s modified Eagle medium
FCS
fetal calf serum
TC
taurocholic acid
HGM
hepatocyte growth medium
HbeAg
hepatitis B e antigen
HbsAg
Hepatitis B surface antigen
GE
genome equivalents
ELISA
enzyme linked immunosorbent assay
PFA
paraformaldehyde
PBS
phosphate buffered saline
RT
room temperature
HbcAg
Hepatitis B core antigen
BSA
bovine serum albumin
PCC
Pearson’s correlation coefficient
GC
glycocholic acid
UDC
ursodeoxycholic acid
TUDC
tauroursodeoxycholic acid
GUDC
glycoursodeoxycholic acid
DHC
dehydrocholic acid
EZ
ezetimibe
TLC
taurolithocholic acid
OATP
organic anion transporting polypeptide
PBC
primary biliary cirrhosis
pp
post preparation
DOX
Doxycycline
Keywords
Hepatitis B virus
Receptor
Infection
NTCP
ASBT
SOAT
Therapy
Bile acids
Ezetimibe
Transport
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© 2014 European Association for the Study of the Liver. Published by Elsevier B.V.