Clinical ResearchGenetics and Statin EffectsThe SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects
Genetics and Statin Effects
Under an Elsevier user license
open archive
Key Words
hydroxymethylglutaryl-CoA reductase inhibitors
pharmacogenetics
single nucleotide polymorphisms
adverse events
clinical trial
myopathy
Abbreviations and Acronyms
AE
adverse event
CAE
composite adverse event
CK
creatine kinase
FDR
false discovery rate
LDL
low-density lipoprotein
MAF
minor allele frequencies
SNP
single nucleotide polymorphism
Cited by (0)
This work was supported by institutional funds from the Duke Institute for Genome Sciences & Policy. Dr. Voora was supported by an NIH T32 training grant (T32HL007101). Dr. Shah received unrestricted research funding from Medtronic, Inc. This trial was conducted by Genaissance Pharmaceuticals, which is now a part of Clinical Data, Inc., and all analyses were performed by investigators at Duke University. Two authors (Drs. Reed and Salisbury) are employees and shareholders of Clinical Data, Inc. Paul Thompson, MD, served as Guest Editor for this article.
Copyright © 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.