Original articleAlimentary tractEffect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation
Alimentary tract
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open access
Keywords
Guanylate Cyclase-C
IBS-C
Abdominal Pain
Bloating
Abbreviations used in this paper
AE
adverse event
ANCOVA
analysis of covariance
BM
bowel movement
cGMP
cyclic guanosine monophosphate
CMH
Cochran–Mantel-Haenszel
GC-C
guanylate cyclase-C
IBS
irritable bowel syndrome
IBS-C
irritable bowel syndrome with constipation
ITT
intent to treat
IVRS
interactive voice response system
LOCF
last observation carried forward
NNT
number needed to treat
NRS
numerical rating scale
QOL
quality of life
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Conflicts of interest The authors disclose the following: Jeffrey Johnston, Caroline Kurtz, James MacDougall, Bernard Lavins, and Mark Currie are employees of Ironwood Pharmaceuticals and own stock/stock options in Ironwood Pharmaceuticals. Steven Shiff is an employee of Forest Laboratories and owns stock/stock options in Forest Laboratories. Satish S. C. Rao participated as a principal investigator and has served on the advisory boards and received honoraria from Ironwood Pharmaceuticals and Forest Research Institute. Eamonn M. M. Quigley has served on the advisory boards for Ironwood Pharmaceuticals and Forest Research Institute.
Funding Supported by Forest Research Institute and Ironwood Pharmaceuticals, Inc.