Structure–activity relationship studies of small-molecule inhibitors of Wnt response
Graphical abstract
SAR studies of IWR-1 are described.
Section snippets
Acknowledgments
We thank UT Southwestern Medical Center, NIH (NCI P01-CA095471, NIGMS R01-GM079554, NIGMS R01-GM076398), American Cancer Society (RSG GMC-112251) and Welch Foundation (I-1596, I-1665) for financial support. L.L. is a Virginia Murchison Linthicum Scholar in Medical Research and C.C. is a Southwestern Medical Foundation Scholar in Biomedical Research. We thank Michael Dodge for critical reading of this Letter.
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