Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors
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Graphical abstract
This work describes the synthesis and pharmacological evaluation of heteroarylazole N-phenylpiperazines 4–24 as multi-target ligands potentially useful for the treatment of schizophrenia. Among the compounds studied, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia positive symptoms treatment without cataleptogenic effects.
Keywords
Atypical antipsychotic drugs
Schizophrenia
N-Phenylpiperazine derivatives
1-Arylpyrazole
1-Aryl-1,2,3-triazole
Imidazo[1,2-a]pyridine
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