ReviewRecent developments in adenosine receptor ligands and their potential as novel drugs☆
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Research Highlights
► Potent, selective agonists and antagonists for all four AR subtypes have been developed. ► Prodrug approaches may lead to improved bioavailability. ► Regadenoson, an A2A-selective agonist was approved for myocardial perfusion imaging. ► Several adenosine receptor agonists and antagonists are currently evaluated in clinical trials. ► AR ligands are developed for CV, neurodegenerative and inflammatory diseases and cancer.
Keywords
Adenosine receptor
Agonist
Antagonist
Clinical trial
Medicinal chemistry
G protein-coupled receptor
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This article is part of a Special Issue entitled: “Adenosine Receptors”.
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