Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 8, August 2011, Pages 879-887
ReviewNuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation☆,☆☆
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Research Highlights
► Altered nuclear receptor signalling is part of the maternal hepatic adaptations that occur during pregnancy. ► Intrahepatic cholestasis and oestrogen-induced hepatotoxicity in pregnancy have been shown to be associated with reduced FXR and PPAR-α activity. ► Agonists of FXR and PPAR-α signalling pathways are of potential therapeutic benefit to treat metabolic pregnancy disorders.
Keywords
Metabolism
Pregnancy
Nuclear receptors
Bile acids
Oestrogens
Cholestasis
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- ☆
The authors have nothing to disclose.
- ☆☆
This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
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