The Interaction of Cancer Chemotherapy Agents with Mononuclear Phagocytes

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This chapter discusses the interaction of cancer chemotherapy agents with mononuclear phagocytes. Cells of the monocyte-macrophage lineage represent a primitive first line of defense, maintained and refined in evolution. In addition, in higher organisms, phagocytic cells have become integrated into subsequently evolved specialized mechanisms of defense, while retaining their basic role of primary line of resistance. Cooperation between lymphoid cells and macrophages occurs at different levels in the genesis of immune reactions and, in inflammatory sites, they play important roles in the expression of cell-mediated immune reactions. The role played by macrophages in resistance against infectious agents is well recognized. Macrophages can be identified in virtually every anatomic compartment and there are regional differences in their biochemistry, morphology, and function. Such differences are particularly prominent when widely differing milieus, such as the lung alveoli and the peritoneal cavity, are considered.

References (132)

  • A.N. Bhisey et al.

    Exp. Cell Res.

    (1971)
  • S. Bovornkitti et al.

    Dis. Chest

    (1960)
  • D.J. Cameron et al.

    Int. J. Immunopharmacol.

    (1981)
  • R. Evans
  • R. Evans et al.
  • A.E. Gassmann et al.

    Blood

    (1975)
  • R. Goldman et al.

    Biochim. Biophys. Acta

    (1978)
  • R. Keller
  • E.S. Kleinerman et al.

    Lancet

    (1980)
  • McCarthyP.L. et al.

    Cell. Immunol.

    (1979)
  • A. Mantovani et al.

    Eur. J. Cancer

    (1976)
  • A. Mantovani et al.

    Eur. J. Cancer

    (1976)
  • A. Mantovani et al.

    Int. J. Immunopharmacol.

    (1980)
  • A. Mantovani et al.
  • F.R. Orsini et al.

    Immnnopharmacology

    (1979)
  • F.R. Orsini et al.

    Immunopharmacology

    (1980)
  • P. Alexander

    Cancer

    (1977)
  • J.F. Bach

    “The Mode of Action of Immunosuppressive Agents.”

    (1975)
  • J.E. Balow et al.

    J. Exp. Med.

    (1973)
  • J.E. Balow et al.

    J. Clin. Invest.

    (1975)
  • J.E. Balow et al.

    Immunology

    (1977)
  • M.C. Berenbaum

    Clin. Exp. Immunol.

    (1971)
  • Blussé van Oud AlblasA. et al.

    J. Exp. Med.

    (1981)
  • A. Blussé van OudAlblas et al.

    J. Reticuloendothel. Soc.

    (1981)
  • C. Bordignon et al.

    Clin. Exp. Immunol.

    (1980)
  • C. Bordignon, F. Villa, M. Introna, R. Avallone, A. Mantovani, (1981). Clin Exp. Immunol., in...
  • Y. Borel et al.

    J. Immunol.

    (1964)
  • M.A. Bray et al.

    Br. J. Pharmacol.

    (1976)
  • T.E. Brown et al.

    Transplantation

    (1976)
  • W.C. Buhles et al.

    J. Reticuloendothel. Soc.

    (1977)
  • I. Carr
  • W.J. Casey et al.

    Immunology

    (1971)
  • V.C. Chambers et al.

    Cancer Res.

    (1969)
  • H.N. Claman

    N. Engl. J. Med.

    (1972)
  • S. Cohen et al.

    “Biology of the Lymphokines.”

    (1979)
  • A. Di Marco

    Antimicrob. Agents Chemother.

    (1978)
  • B.E. Domeyer et al.

    Cancer Res.

    (1980)
  • M.J. Ehrke et al.

    Fed. Proc. Fed. Am. Soc. Exp. Biol.

    (1978)
  • L.H. Einhorn et al.

    N. Engl. J. Med.

    (1979)
  • G.B. Elion et al.
  • R. Evans

    J. Gen. Virol.

    (1967)
  • R. Evans

    Transplantation

    (1972)
  • R. Evans

    Br. J. Cancer

    (1977)
  • R. Evans

    Int. J. Cancer

    (1977)
  • R. Evans

    Int. J. Cancer

    (1978)
  • R. Evans

    Am. J. Pathol.

    (1980)
  • R. Evans et al.

    Cancer Res.

    (1980)
  • T. Facchinetti et al.

    Cancer Res.

    (1978)
  • A.S. Fauci et al.

    J. Clin. Invest.

    (1974)
  • B. Fisher et al.

    J. Natl. Cancer Inst.

    (1975)

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