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Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid

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Abstract

We report on the pharmacokinetics of PP formation and elimination in 4 patients after the administration of oral ALA (60 mg kg−1). After a brief distribution phase, plasma PP levels decline (half life=8 h) and was almost undetectable by 48 h post-administration. This confirms pharmacokinetic clinical data which show that ALA results in a shortened interval of skin photosensitization compared with other sensitizers such as Photofrin and ‘HPD’. A brief summary of other clinical-toxicity findings is reported.

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