Trends in Microbiology
CommentBacterial phospholipases
References (3)
Trends Microbiol.
(1997)
Cited by (11)
Delivery of antibiotics with polymeric particles
2014, Advanced Drug Delivery ReviewsCitation Excerpt :The TLN further delivered the drug into bacteria-infected cells and efficiently released the drug to kill intracellular bacteria. Bacterial phosphatase and phospholipase are of paramount importance for the normal function of metabolic and signaling pathways and are a key virulence factor of pathogens [158–160]. We have developed a bacterial phosphatase and phospholipase-responsive multifunctional nanogel for targeted antibiotic delivery to macrophages to treat bacterial infections [161].
Clostridium perfringens alpha-toxin induces the release of IL-8 through a dual pathway via TrkA in A549 cells
2012, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Clostridium perfringens alpha-toxin has been shown to be a virulence factor required for the development of gas gangrene [1,2].
Interactions between Clostridium perfringens spores and Raw 264.7 macrophages
2012, AnaerobeCitation Excerpt :However, phagosytosed C. perfringens cells do not co-localize with the late endosomal and lysosomal marker LAMP-1 [5], but instead can escape the phagosome, surviving J774-33 cell killing under either aerobic or anaerobic conditions [5]. The main virulence factors involved in C. perfringens cells’ escape from and survival in the phagosome of macrophages are pospholipase C (PLC) [9] and perfringolysin O (PFO), a thiol-activated cytolysin [10]. Indeed, strains with mutations in the genes encoding PLC (plc) and PFO (pfoA) have reduced virulence in a mouse model of gas gangrene [7,11].
Expression and purification of functional Clostridium perfringens alpha and epsilon toxins in Escherichia coli
2011, Protein Expression and PurificationCitation Excerpt :The C. perfringens species is divided into 5 types, A through E, on the basis of the production of the 4 major lethal toxins, namely, alpha-, beta-, epsilon-, and iota-toxin [2]. Alpha-toxin (CPA), produced by C. perfringens types A and D, is a very important pathogenic factor with the biological activities of phospholipase C (PLC) and sphingomyelinase as well as hemolysis, lethality, and dermonecrosis [1,4]. It can cause gas gangrene, which is a life-threatening infection that presents with fever, pain, edema, myonecrosis, and gas production [5].
Clostridium perfringens alpha-toxin-induced hemolysis of horse erythrocytes is dependent on Ca<sup>2+</sup> uptake
2003, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Clostridium perfringens alpha-toxin, which possesses hemolytic, lethal, dermonecrotic and cytotoxic activities and in addition phospholipase and sphingomyelinase activities, is thought to play an important role in gas gangrene [1–5].