Current Biology
Volume 13, Issue 2, 21 January 2003, Pages R71-R73
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Apoptosis: Mitochondrial Membrane Permeabilization – The (W)hole Story?

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Abstract

One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate on the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.

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