Design and synthesis of novel dihydropyridine alpha-1A antagonists

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Abstract

A series of analogs of SNAP 5150 containing heteroatoms at C2 or C6 positions is described. Herein, we report that the presence of alkyl substituted heteroatoms at the C2(6)-positions of the dihydropyridine are well tolerated. In addition, 15 inhibited the phenylephrine induced contraction of dog prostate tissue with a Kb of 1.5 nM and showed a Kb (DBP, dogs, μg/kg)/Kb (IUP, dogs, μg/kg) ratio of 14.82.5.

The design and synthesis of dihydropyridine analogs containing heteroatoms at the C26-position are described.

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