Synthesis and pharmacological activity of the stereoisomers of GP-88, a propafenone-type modulator of multidrug resistance
All four stereoisomers of the propafenone-type MDR-modulator GP-88 were synthesized using a combined approach with chiral pool building blocks and an acetalic protective group. Those isomers with (R)-configuration in the propanolamine moiety showed twofold higher activity than the corresponding (S)-isomers.
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