Nicotinanilides as inhibitors of neutrophil chemotaxis
This communication describes the synthesis and SAR of a novel series of substituted nicotinanilides as potent modulators of GRO-α-driven human neutrophil chemotaxis. Compound 5b was a potent inhibitor of chemotaxis (IC50=42 nM) and demonstrated high selectivity over the chemoattractant polypeptide N-formyl-methionyl-leucyl-phenylalanine (IC50>40 μM).
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Acknowledgements
The authors would like to thank Dr. Breda Twomey for performing assays on these compounds and Mr. Ted Baughman and Dr. Scott Jeffrey, for helpful discussions.
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