The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist
This paper is dedicated to the memory of the outstanding chemist Robert A. Mack.
The 5-HT3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at α7 nicotinic receptors. Quinuclidine analogues (1 and 2) are also potent and selective partial agonists at α7 nAChRs.
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Acknowledgements
The mouse nAChR α7 clone was kindly provided by Dr. Avi Orr-Urtreger at the Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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