Phosphoinositide kinases

doi:10.1016/S0955-0674(96)80060-3

Current Opinion in Cell Biology

Volume 8, Issue 2, April 1996, Pages 153-158

https://doi.org/10.1016/S0955-0674(96)80060-3 Get rights and content

Abstract

Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.

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Phosphoinositide kinases

Abstract

J Biol Chem

Cell

Science

J Biol Chem

J Biol Chem

Mol Biol Cell

Cell

Proc Natl Acad Sci USA

Nature

Cell

J Biol Chem

Curr Biol

EMBO J

J Biol Chem

Nature

Proc Natl Acad Sci USA

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

Science

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

EMBO J

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Science

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

Mol Cell Biol

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity

EMBO J

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities

J Biol Chem

A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae

J Biol Chem

When is a lipid kinase not a lipid kinase? When it's a protein kinase

Cell

Control of p70 S6 kinase by kinase activity of FRAP in vivo

Nature

The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol kinase activity

J Biol Chem