ExperimentalAnticonvulsant and Neuronal Protective Effects of Propofol on Experimental Status Epilepticus
Section snippets
Animals
The experimental procedures were conducted in 30 adult Sprague-Dawley rats (body weight: 250–500 g; Taconic Farms, NY, USA). All animals were maintained on a 12-hour light–dark cycle with an average room temperature of 23°C, humidity of 55%, and food and water ad lib. Experiments were conducted according to our Institutional Animal Care and Use Committee (IACUC) and Center for Laboratory Animal Science (CLAS) guidelines and approved protocols.
Surgery for Insertion of Intravenous Catheter
Rats were anesthetized with chloral hydrate (.3
Results
In group I rats (pretreatment), the latency to seizure onset in propofol-treated rats was not different from controls. Seizures occurred 65 ± 6 minutes after injection of KA in propofol-treated rats and 78 ± 12 minutes in controls. Furthermore, seizure severity was not worsened by propofol pretreatment. Additionally, propofol-treated rats had a lower rate of SE than controls: SE occurred in four of five control rats and only three of 12 of experimental animals (Fig. 1).
In group II rats
Discussion
Medically refractory SE causes irreversible neuronal damage and is potentially life-threatening 3, 26, 27. Therefore, new drugs are currently sought for its treatment 6, 7. Propofol, a hypnotic anesthetic agent, has met wide favor in anesthesia practice since its introduction in 1981 [28]. Its fast-acting properties including a distribution half-life of 2–4 minutes and quick metabolic clearance of 30–60 minutes, make it particularly desirable, as it allows patients to recover promptly even
Acknowledgements
This work was partially presented at the American Epilepsy Society, 1995 Annual Meeting.
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