Antisense confirmation of μ- and κ-opioid receptor mediation of morphine's effects on body temperature in rats
References (36)
- et al.
Intraventricular treatment with an AS oligodeoxynucleotide to κ-opioid receptors inhibited κ-agonist-induced analgesia in rats
Brain Res.
(1994) - et al.
Stress-induced changes in the analgesic and thermic effects of opioid peptides in the rat
Brain Res.
(1986) - et al.
Effects of dynorphins on body temperature of rats
Pharmacol. Res. Commun.
(1988) - et al.
Hypothermia elicited by some prodynorphin-derived peptides: Opioid and non-opioid actions
Neuropeptides
(1989) - et al.
An antisense oligodeoxynucleotide to μ-opioid receptors inhibits μ-agonist-induced analgesia in rats
Eur. J. Pharmacol.
(1995) - et al.
Antisense oligodeoxynucleotides against μ- or κ-opioid receptors block agonist-induced body temperature changes in rats
Brain Res.
(1995) - et al.
Blockade of U50, 488H analgesia by antisense oligodeoxynucleotides to a κ-opioid receptor
Eur. J. Pharmacol.
(1994) - et al.
Postulated thermoregulatory roles for different opiate receptors in rats
Life Sci.
(1982) - et al.
Body temperature effects of opioids in rats: Intracerebroventricular administration
Pharmacol. Biochem. Behav.
(1986) - et al.
Effect of μ-, κ-, and δ-selective opioid agonists on thermoregulation in the rat
Pharmacol. Biochem. Behav.
(1992)
Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the μ receptor
Life Sci
Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6β-glucuronide receptor
FEBS Letters
Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor
Neuron
Effect of intrahypothalamic injection of [D-Ala2,D-Leu5]enkephalin on feeding and temperature in the rat
Eur. J. Pharmacol.
Antisense oligodeoxynucleotide to a δ -opioid receptor selectively blocks the spinal antinociception induced by δ-, but not μ- or κ-opioid receptor agonists in the mouse
Eur. J. Pharmacol.
Antisense oligonucleotide strategies in neuropharmacology
TiPS
Isobolographic superadditivity between delta and μ opioid agonists in the rat depends on the ratio of compounds, the μ agonist and the analgesic assay used
J. Pharmacol. Exp. Ther.
Functional effect of antisense oligodeoxynucleotides to opioid receptors in rats
Cited by (25)
Excessive sweating following intrathecal μ agonists: Effective atropine management
2016, Egyptian Journal of AnaesthesiaCitation Excerpt :Experimentally, IT Mo has a biphasic thermal pattern. That high doses produce hypothermia by κ-opioid receptors stimulation [51], while the low doses produce hyperthermia by μ-opioid receptors activation, increasing thermoregulatory set point, oxygen consumption and peripheral vasoconstriction [52]. This hyperthermia is maximum at 2–3 h after subcutaneous morphine in rats [53].
Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus
2008, Brain ResearchCitation Excerpt :In parallel with the sleep–wake response to morphine, low doses of morphine (4–16 mg/kg, i.v) induce hyperthermia, whereas high doses (> 30 mg/kg, i.v) produce hypothermia (Martin and Morrison, 1978). Chen et al. (1996) previously showed that icv injection of antisense oligodeoxynucleotide against the mu receptor (nucleotides 1–18 of the coding region of the mu receptor) prevented morphine-induced hyperthermia, and icv injection of an antisense oligodeoxynucleotide against kappa receptors (4–21 of the coding region of the kappa receptor) blocked morphine-induced hypothermia. These blocking effects were later replicated by microdialysis of antisense oligodeoxynucleotides for mu and kappa opioid receptors into the preoptic area (Xin et al., 1997).
Agmatine blocks morphine-evoked hyperthermia in rats
2007, Brain ResearchCitation Excerpt :The effect of agmatine was blocked by idazoxan, suggesting a significant role for imidazoline receptors. Because low doses of morphine produce hyperthermia by activating mu receptors (Chen et al., 1996; Geller et al., 1983; Rawls et al., 2003; Spencer et al., 1988), these data support the existence of mu opioid–imidazoline receptor interactions and reveal that these interactions regulate morphine-evoked hyperthermia. Animal use procedures were conducted in strict accordance with the NIH Guide for the Care and Use of Laboratory Animals.
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice
2004, European Journal of PharmacologyCitation Excerpt :For example, morphine-induced hypothermia in mice is mediated through composite actions on mu, delta and kappa opioid receptors, based on the ability of selective opioid receptor antagonists to block hypothermia (Baker and Meert, 2002). In rats, antisense oligodeoxynucleotide to kappa opioid receptors blocked the hypothermic effects of high (i.e., 30 mg/kg) doses of morphine (Chen et al., 1996). Thus, morphine-induced hypothermia may be mediated through multiple opioid receptor subtypes, especially at higher doses.