Letter to NeuroscienceEstradiol reduction of α2-adrenoceptor binding in female rat cortex is correlated with decreases in α2A/D-adrenoceptor messenger RNA
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Acknowledgements
This work was supported by Grants HD29856, MH41414 and RSDA MH00636 to AME, by American Diabetes Association and Goldsmith Foundation Grant to GBK and by the Department of Neuroscience, Albert Einstein College of Medicine. The authors acknowledge the generous contribution of RG20 cDNA by Dr Stephen M. Lanier. We also express our thanks to Dr Margaret J. Lin for sequencing the RG20 PCR product.
References (28)
- et al.
Perikaryal and synaptic localization of α2A-adrenergic receptor-like immunoreactivity
Brain Res.
(1994) - et al.
Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance
Prog. Brain Res.
(1991) - et al.
Catecholamines and attention II: pharmacological studies in normal humans
Neurosci. Biobehav. Rev.
(1987) - et al.
Gonadal steroids and attentional mechanisms in young domestic chicks
Physiol. Behav.
(1988) - et al.
A thermodynamic analysis of estrogen regulation of α2-adrenoceptor binding
Brain Res.
(1995) - et al.
Artificial reductant enhancement of the Lowry method for protein determination
Analyt. Biochem.
(1986) - et al.
Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
Meths Enzymol.
(1987) - et al.
The distribution and significance of CNS adrenoceptors examined with in situ hybridization
Trends Pharmac. Sci.
(1996) - et al.
Distribution of α2-adrenergic receptor subtype gene expression in rat brain
Molec. Brain Res.
(1994) - et al.
Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to α2-adrenoceptor in rat cerebral cortical membranes
Eur. J. Pharmac.
(1994)
α2-Adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates
Science
Subtypes of α1- and α2-adrenergic receptors
Fedn Proc. Fedn Am. Socs exp. Biol.
Pharmacological manipulations of the alpha 2-noradrenergic system. Effects on cognition
Drugs Aging
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2016, Brain ResearchCitation Excerpt :Aside from its role in reproduction, estrogen regulation of adrenergic receptors in LC target regions implicated in arousal, attention, and vigilance, has received less attention. Yet, there is evidence that ovariectomized females treated with estrogen have reduced cortical postsynaptic α2-adrenoceptor binding and mRNA relative to their untreated counterparts (Ansonoff and Etgen, 2001; Karkanias et al., 1997, but see Shansky et al., 2009). Additionally, in cycling females, compared to ovariectomized females and intact males, β-adrenergic receptor binding is decreased in cortical membranes and there is less β-adrenergic receptor stimulated cAMP (Wagner and Davies, 1980).