Alterations in urinary bladder M2-muscarinic receptor protein and mRNA in 2-week streptozotocin-induced diabetic rats
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Acknowledgements
This study was supported by a grant from the National Science Council of the Republic of China (NSC-88-2314-B-006-056).
References (23)
- et al.
Muscarinic acetylcholine receptor subtypes in smooth muscle
Trends Pharmacol. Sci.
(1994) - et al.
Alterations in neural pathways to the urinary bladder of the rat in response to streptozotocin-induced diabetes
J. Auton. Nerv. Syst.
(1994) - et al.
Alterations in urinary bladder synaptosomal neurotransmitter concentrations in two-week streptozotocin-induced diabetes rats
Neurosci. Lett.
(1996) - et al.
Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth bladder
Am. J. Physiol.
(1993) - et al.
Identification of a family of muscarinic acetylcholine receptor genes
Science
(1987) Diagnosis of urinary bladder dysfunction in diabetes mellitus
Ann. Int. Med.
(1980)- et al.
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-k1 cells
Mol. Pharmacol.
(1989) - et al.
Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart
Arch. Pharmacol.
(1991) - et al.
Reversibility of diabetes- and diuresis-induced alterations in rat bladder dome muscarinic receptors
Diabetes
(1994) - et al.
Pirenzepine distinguishes between different subclasses of muscarinic receptors
Nature
(1980)
Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
Br. J. Pharmacol.
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