Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells
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Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol
2018, Toxicology and Applied PharmacologyCitation Excerpt :This suggests that resveratrol has additional targets linked to the adverse effects on EBs. Among the other potential targets, of particular interest for future studies, are AMPK (Baur et al., 2006; Dasgupta and Milbrandt, 2007), PDE (Park et al., 2012), mechanistic target of rapamycin (mTOR; Liu et al., 2010), and mitogen-activated protein kinase (MAPK; Miloso et al., 1999), as they are key regulators of signaling pathways essential for proper embryo development. One of the health benefit claims of resveratrol is amelioration of diabetes (Szkudelski and Szkudelska, 2015; Öztürk et al., 2017).
Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells
2017, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Here we found that OXYRES was able to activate p38 in both neuroblastoma cells and inactivate ERK1/2, and JNK pathway. When we compare our findings with previous RES experiments, RES upregulated the activity of ERK1 and ERK2 at lower doses but not at higher doses except for p38 MAPK [45] and against pancreatic cancer cells, it downregulated p38 phosphorylation [46]. We showed that pre-treatment with p38 inhibitor SB203580 significantly prevented OXYRES-induced phosphorylation of p38, and autophagy and apoptosis, indicating that OXYRES-induced autophagy and apoptosis is dependent on a p38-activated MAPK cascade.
Resveratrol: Multiple Activities on the Biological Functionality of the Cell
2016, Nutraceuticals: Efficacy, Safety and ToxicityThe molecular targets of resveratrol
2015, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :As with other effectors, it seems that the dosage of Rsv is key to determine MAPK activity. For example, doses up to the low micromolar range might increase ERK signaling, whereas Rsv is inhibitory at the most commonly used, higher, doses (> 50 μM) [133]. This clearly suggests that the impact on this path might be indirect, where MAPKs might act as integrators of diverse signaling paths triggered by Rsv.
Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry
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