Propentofylline attenuates microglial reaction in the spinal cord induced by middle cerebral artery occlusion
Section snippets
Acknowledgements
This work is supported by a research grant (RP950363) from the National University of Singapore.
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Role of spinal glial cells in excitability of wide dynamic range neurons and the development of neuropathic pain with the L5 spinal nerve transection in the rats: Behavioral and electrophysiological study
2019, Physiology and BehaviorCitation Excerpt :It appears that propentofylline prevents the neuronal activation from evoked responses to electrical stimulation up to the long-lasting potentiation of dorsal horn WDR neurons in the neuropathic rats. Several studies have shown that propentofylline attenuates the activation of astrocyte and microglial cells in the spinal cord induced by an ischemia model [17,42]. It has been shown that this agent inhibits the phosphodiesterase and increases the concentration of the cyclic AMP (cAMP) which can promote nerve regeneration [24].
Chapter 13 Role of Microglia in Amyotrophic Lateral Sclerosis
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2002, Advanced Drug Delivery ReviewsNeuronal and glial response in the rat hypothalamus-neurohypophysis complex with streptozotocin-induced diabetes
2002, Brain ResearchCitation Excerpt :The upregulation of CR3 receptors on these cells may be linked to an increased phagocytosis of degenerating cells or axons as demonstrated by Dheen et al. [12–14]. It is well documented that microglial cells are sensors of pathological events as they respond vigorously and swiftly to subtle changes in their ambient environment [23,29,40]. The absence of OX-6 positive cells in the brain suggests that MHCII antigens were not induced in PVN and SON in diabetes.
Microglia: Its development and role as a neuropathology sensor
2001, Progress in Brain ResearchNitric oxide, microglial activities and neuronal cell death in the lateral geniculate nucleus of glaucomatous rats
2000, Brain ResearchCitation Excerpt :Microglia is thought to be a pathology sensor, a macrophage and an immune surveillance cell in the central nervous system. It shows vigorous and swift response to subtle changes in its ambient environment, and become activated in injured or pathological neural tissue [33,39,40,53]. It is also found to respond to neuronal degeneration following glaucoma [37,39,50,51].