Spinal analgesic activity of orphanin FQ/nociceptin and its fragments
Section snippets
Acknowledgements
We thank Drs. J. Posner and R. Rapaka for their assistance with these studies. This work was supported, in part, by the National Institute on Drug Abuse by a research grant (DA07242) and a Research Scientist Award (DA00220) to G.W.P. and a Research Scientist Development Award (DA00310) to G.C.R.
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Central N/OFQ-NOP Receptor System in Pain Modulation
2016, Advances in PharmacologyAntinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception
2011, PeptidesCitation Excerpt :The complex pharmacology of N/OFQ also suggests that some of the observed effects may be exerted by shorter fragments of N/OFQ. Indeed, there are some reports that N-terminal fragments, administered spinally or peripherally, produce antinociceptive activity [20,22,44]. In addition, nociceptive desensitization evoked by repeated injections of capsaicin is prevented by intraplantar injections of N-terminal fragments of N/OFQ [44].
Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr<sup>6</sup>] γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice
2009, Brain ResearchCitation Excerpt :The mRNA for NOP receptor was also found in the dorsal spinal cord (Bunzow et al., 1994; Wick et al., 1995), suggesting an important role for N/OFQ–NOP receptor system in the modulation of nociceptive signals at spinal level. N/OFQ was reported to induce behavioral responses (Sakurada et al., 1999b), allodynia and thermal hyperalgesia in conscious mice (Hara et al., 1997; Sakurada et al., 1999a), facilitate the flexor reflex (Xu et al., 1996) at low doses, and produce analgesia (King et al., 1997; Nazzaro et al., 2007; Xu et al., 1996), anti-hyperalgesic and anti-allodynic effects (Hao et al., 1998) at high doses. In the present study, we have observed that intrathecal [Tyr6] γ2-MSH(6-12) elicited hyperalgesia as assayed by tail withdrawal test and nociceptive behavioral responses including biting, licking and scratching in mice.
Nociceptin produces antinociception after spinal administration in amphibians
2009, Pharmacology Biochemistry and Behavior